RESEARCH


Dr. Lee and his group members have been developing the microarray 3D bioprinting technology in predicting human toxicology. Our research is focused on the following areas:

1) Develop 3D human cell printing on microarray chips for tissue engineering and disease modeling

  • Creating brain tissue replicas using stem cells for developmental toxicology
  • Creating liver tissue replicas via layered hepatic cell printing and human liver organoid culture
  • Generating tumor micro-tissues with patient cancer cells for personalized cancer therapy
  • 2) Establish high-content imaging (HCI) with 3D-cultured human cells

    3) Synthesize tunable hydrogels ("bioink") for microarray 3D bioprinting

    4) Develop viral gene delivery systems to study individual-dependent, adverse drug responses

    Microarray Chip Platform

    3D Cell/Tissue Culture on the 384PillarPlate

    Advantages of Microarray 3D Bioprinting

  • Rapid creation of human tissue constructs via novel microarray 3D printing technology
  • Approximately 1000-fold miniaturization of human tissues, saving expensive resources including human cells, growth factors, and extracellular matrices
  • High-throughput, systematic study of cellular microenvironments for tissue engineering and regenerative medicines
  • High-throughput, high-content imaging of miniaturized human tissue constructs for mechanistic studies
  • Commercial Applications of Miniaturized Human Tissue Constructs

  • Predictive assessment of drug toxicity, efficacy, and pharmacokinetics for preclinical evaluations on bioprinted tissue constructs
  • Human disease modeling on bioprinted tissue constructs
  • Systematic study of cellular microenvironments for tissue engineering and regenerative medicines
  • High-throughput, high-content screening of drug candidates and environmental toxicants
  • Applications of Microarray Biochips

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